Bodo v. Ehrlich1, Jürgen Vormann2
- Internal-Medicine Clinic, Kempten, Germany
- Institute for Prevention and Nutrition, Ismaning/München, Germany
In the concept of „slow metabolic diseases“ Mg plays an important role for vascular aging especially dysfunction (functional and structural) of the microvascular system. AIX – „augmentation-index“ is a clinical parametric tool for long-term monitoring of microvascular function in patients. With determination of the „Augmentation-index (AIX) “measured by pulse-wave -analysis (pwa) long-term monitoring of microvascular function is possible. Preliminary own studies had shown an association of elevated AIX, microvascular dysfunction and 9 years Mg depletion in a cohort of aged patients with dementia.
From an 8 years period (2015-2023) of pulse wave analysis (pwa) (IEM device Aachen Germany) and serum-Mg analysis in an unselected real life medical office population we retrospectively analysed patient data for the proof of concept study: the AAA-project – „Allgäu Altered Aging project“. For that data from 108 patients (mean age about 60 years) with moderate initial Mg deficiency and with several completed pulse-wave-analyses over time as well as data from serum-Mg-measurements were retrospectively analysed. For all patients oral Mg supplementation was recommended. Average recommended Mg supplementation was 18mmol/day. Patients showing increase of serum-Mg (indicating compliance) where classified as verum group (V) and those showing descending or unchanged serum Mg (indicating non-compliance) where classified as control group (C). In the V-group increasing serum-magnesium with supplementation over a mean duration of 4 yrs/2mo resulted in decreased AIX. In the C-group decreasing serum magnesium was connected to an increase of AIX. Results were not different between males/females. In contrast to short term (6 month) Mg supplementation (Joris 2016, Cunha 2016, Schutten 2022) our presented long term Mg supplementation study (>4 years) resulted in detectable improvement/slowing of AIX microvascular aging.