Kisters K^1,2,3, Kraus A¹, Micke O¹, Gröber U^1,2

Magnesium is involved in about 600 enzymatic and metabolic reactions (1-7). In patients at risk a magnesium deficiency has to be taken into account, e.g. cardiovascular disorder (2-5).

Diagnosis can made by laboratory, anamnesis (drugs) or clinical symptoms. A magnesium therapy is then often of benefit. Ionized magnesium measurements are a new tool to diagnose a magnesium deficiency (Phox plus apparatus, Nova, Biomedical, USA). This new method can be easily performed in 1 ml blood with a point–of–care unit. Analytic specification for imprecision CV% is only 3.0.

In several studies no correlation between serum and ionized magnesium concentrations in patients existed (3-5).

In conclusion normal serum magnesium does not exclude a magnesium deficiency. The determination of ionized magnesium might be a better tool in this context, e.g. as an early marker for a magnesium deficiency.

References

1. Kisters K, Gröber U, Gremmler B et al. Ionized magnesium deficiency in elderly hypertensive patients in a pilot study. Nutr Food Sci J 2020; 3(2): 129-134
2. Rosanoff A, Plesset MR. Oral magnesium supplements decreases high blood pressure (SBP> 155 mmHg) in hypertensive subjects on  antihypertensive medications: a target meta-analysis. Magnes Res 2013; 26:93-99
3. Kisters K, Gremmler B, Wroblewski F et al. Ionized magnesium in elderly hypertensives.  J Hypertens. 2021; 26:39(3):e321
4. Kisters K, Kisters L, Werner T et al. Increased serum vitamin D concentration under oral magnesium  therapy in elderly hypertensives. Magnes Res. 2020; 33(4):131-132
5. Kisters K, Gröber U, Vormann J et al. Low ionized magnesium, vitamin D an interleukin 6 concentrations in elderly hypertensive patients. Trace Elem Electrolyt. 2021; 38(2):63-67
6. Kisters K, Kisters L, Werner T, Gröber U. Magnesium verbessert Vitamin D – Konzentration bei älteren Hypertonikern. Zs. f. Orthemol. Med. 2021; 19: 26-28
7. Micke O, Vormann J, Kraus T. Kisters K. Serum magnesium: time for a standardized and evidence-based reference range. Magnes Res 2021; Aug 26. doi: 10.1684/mrh.2021.0486