Kisters K^1,3, Gremmler B¹, Tokmak F², Gröber U³

¹ St. Anna-Hospital, Medizinische Clinic I, Hospitalstraße 19, 44649 Herne
² MVZ Nephrology, Nordring 49-51, 45894 Gelsenkirchen
³ Academy for Micronutrients, Zweigertstr. 45, 45130 Essen

1 to 2 millions of patients in Germany suffer from dementia (1, 2). Due to recent investigations 10 millions of patient in Europe and 40 millions of patients worldwide with increasing tendency are registered.
When disturbances in our central nervous system or a dementia occur magnesium handling is of special importance (3, 4). Magnesium has been recognized as a cofactor for more than 600 enzymatic reactions, where it is crucial for adenosine triphosphate (ATP) metabolism. Magnesium is required for DNA and RNA synthesis, reproduction, and protein synthesis. In the cerebrum NMDA receptors and taurine are influenced by magnesium. Moreover, magnesium is essential for the regulation of muscular contraction, blood pressure, insulin metabolism, cardiac excitability, vasomotor tone, nerve transmission and neuromuscular conduction. Imbalances in magnesium status – primarily hypomagnesemia as it is seen more common than hypermagnesemia – might result in unwanted neuromuscular, cardiac or nervous disorders. Based on magnesium`s many functions within the human body, it plays an important role in prevention and treatment of a variety of diseases. Low levels of magnesium have been associated with a number of chronic diseases, such as Alzheimer`s disease, migraine headaches and attention deficit hyperactivity disorder or Morbus Parkinson (5).
In addition in liquor cerebrospinalis of patients with dementia lowered magnesium concentrations were measured as compared to controls (p<0.01) (6).
In conclusion a magnesium deficiency has to be avoided in prevention and therapy of various forms of dementia, e.g. Alzheimer`s disease (7).

References
(1) Friedrichsen HP. Alzheimer. OM 1(1): 3-9, 2016
(2) Kisters K, Gröber U. Magnesiummangel und Demenz – Morbus Alzheimer. OM (in press), 2017
(3) Classen HG, Gröber U, Kisters K. Magnesium-Mangel und Arzneimittel. MMP. 35: 2-8, 2012
(4) Gröber U, Kisters K. Neuroenhancement with vitamins and other micronutrients. Pharmakon. 3(3): 231-237
(5) Gröber U, Schmidt J, Kisters K. Magnesium in prevention and therapy. Nutrients. 7(9): 8199-8226, 2015
(6) Pollet S, Ermidou Pollet S, Jarolim Maudanz M, Baraliakos X, Kisters K. Blockade of the NMDA receptor, regulation of the calcium flux. Trace Elements Electrolyt. 30(2): 59-65, 2013
(7) Kisters K, Gröber U. Demenz – Präventives und therapeutisches Wirkspektrum von Magnesium. Die Naturheilkunde. 3: 23-26, 2017