MAGIP-Project Greifswald, Germany

Ratzmann GW1, Weinke I2

1 former Kinderklinik Ernst-Moritz-Arndt-Universtät Greifswald und Praxis für Kinder- und Jugendmedizin,
Kinderkardiologie-Kinderrheumatologie, 17498 Neuenkirchen
2 former Neuropädiatrie der Kinderklinik der Ernst-Moritz-Arndt-Universität Greifswald und ehem. Leiterin des
Sozialpädiatrischen Zentrums Vorpommern, Greifstwald c/o MAGIP-Project Greifswald, 17498 Neuenkirchen

In a group of biochemical and clinical well defined newborns with seizures because of magnesium deficiency a follow-up
was made in all cases up to the sixth year of life. Initially pathologic bioelectric activity (EEG) was recorded in 43% (6/14),
at the end of investigation (2. - 6. year of life) normal bioelectrical activity was only seen in 36% (5/14). The first year was
characterized by a marked centralnervous irritability, phases of crying, vegetative dysregulations, and coordinative
disturbances of the CNS, at the end only 2 infants had a normal psychomotoric developmental state. After the second year
in 2 cases severe affect spasms were manifested together with other behavioral deviations and retarded mental functions.
These observations correspond to experimental data that prae- and/or early postnatal magnesium deficiency may result in
cerebral damage.