Hypotheses from practice parameters: Mgs/Cas und QTc Zeit

v. Ehrlich B
Practice of internal Medicine, Kempten/Germany
 

The association of Magnesium depletion with numerous internal medicine diagnoses is much better established than
therapy. Oral Mg supplementation is wearisome. Mg effects can mostly be expected after longer latency. Human
awareness – dependant of this compliance – is mainly influenced by instant effects – Wantability dominates subjective
remembering (1). Where accepted and efficient therapy-alternatives are missing we offered patients with Magnesium
depletion additive parenteral Mg-therapy assuming a quicker perception of the effect. Inhomogenity of diagnosis and
population do not allow assessment of general utility concerning single leading symptoms. Nevertheless we can analyze
what happens with Mg-dependent parameters during this therapy.

Due to our observations changes in Mgs/Cas quotient – serumparameter – and QTc (ECG) – Mg influenced intracellular
parameter –happen. Both practice usable parameters might correlate even with changes within the normal range. We
hypothesize that the chance of improving Mg depletion assoziated disease is reflected better with these two parameters
than with Mgs. Close up improvement facilitates the motivation of patients to continue the following oral Mg
supplementation.

We present data of overall 917 Mg infusion-therapies in 35 patients (23-84ys) – out of this n=28 with series 5-166 x/pt and
7pt acute or short term (1-3x inf). Dosage ascending mostly up to 6,4 or 8mmol/30-40min. No relevant side effects where
observed.

A formula out of Mgs/Cas and QTc could perhaps serve as practical tool to open the grey zone of Mgs 0.76-0,85mmol/l
(„latenter Mg depletion“)to our better clinical estimation. Long term observed patients let us speculate that different
individual aims could be useful as anchor-values for some individuals.

1) D.Kahnemann: Thinking fast and slow , 2011 Farrar,Strauss,Giroux , NY