Kolisek M, Sponder G, Mastrototaro L, Tietjen U, Marak M, Aschenbach JR, Vormann J* Institute of Veterinary Physiology, Freie Universität Berlin, Berlin, Germany *Instititute for Prevention and Nutrition, Ismaning, Germany
Disbalanced magnesium (Mg) homeostasis (DMH) is associated with psychiatric, and neurodegenerative diseases. Molecular entities linking DMH and pathophysiology of these diseases were unknown until now. This changed with the recent identification of ubiquitous Na+/Mg2+ exchanger (NME) SLC41A1 as a possible Parkinson’s disease (PD)-associated protein and the novel association of mutated variants of an important Mg2+ homeostatic factor, cyclin M2 (CNNM2), with familial hypomagnesaemia, schizophrenia and disturbed brain development. This presentation will introduce the data describing interactors of SLC41A1 and CNNM2 and a novel concept of the functional interactions between these two proteins and other factors essential for control of cellular processes, such as autophagy and mitophagy or elimination of ROS, that are being impaired in PD, Alzheimer’s disease (AD) and shizophrenia.